PAHO chikungunya count rises by more than 32,000The number of chikungunya infections in the Americas has increased to 1,343,372, a rise of 32,504, the Pan American Health Organization (PAHO) said in its latest update. The bump in cases was slightly higher than the 28,768-case increase recorded the week before.PAHO’s latest count includes 1,310,925 suspected, 28,910 confirmed, and 3,537 imported cases. Most of the imported cases are from the United States, which has 2,549,13 more than the previous week.The US Centers for Disease Control and Prevention (CDC) said in a Mar 24 update that so far 68 chikungunya cases, all of them travel related, have been reported in 19 states so far this year. No locally transmitted cases have been reported. US territories have reported 52 chikungunya cases this year, all of them locally transmitted infections in Puerto Rico and the US Virgin Islands.Most of the increase this week came from Nicaragua, which submitted 10 weeks’ worth of data, and Colombia.The death toll from the disease remained the same at 184.Mar 28 PAHO update Mar 24 CDC update Saudis report another MERS case; camel serum suggested as treatmentSaudi Arabia reported another MERS-CoV (Middle East respiratory syndrome coronavirus) case today, while researchers raised the possibility of using camel antibodies to treat MERS patients.The latest patient is a 65-year-old expatriate woman in Riyadh who is in stable condition, the Saudi Ministry of Health (MOH) reported. She is not a healthcare worker and had no contact with other MERS patients in healthcare or community settings, but the statement did not indicate whether she had any contact with animals.The MOH also announced the death of a 57-year-old Saudi man in Hofuf whose case was reported earlier. In addition, the ministry noted the recovery of a 50-year-old male expatriate in Najran.The latest events raised the MOH’s cumulative MERS count to 973 cases, with 422 deaths, 532 recoveries, and 19 patients still in treatment or home isolation. Mar 31 MOH statementMeanwhile, researchers reported recently in the Journal of Virology that they used antibodies from camels to protect mice from MERS-CoV and to help infected mice recover from the disease.The authors, from the United States and China, wrote that serum from recovered MERS patients may be useful for treating infected persons but is not readily available, and that most camels in the Arabian Peninsula carry MERS-CoV antibodies because of past infections. They used serum from camels to treat mice infected with human MERS-CoV isolates.”The study, a successful proof-of-concept study, showed that prophylactic or therapeutic treatment with high-titer MERS immune camel sera diminished weight loss and pathological changes in lung tissues, and cleared the infections in the mice,” says a press release from the American Society for Microbiology (ASM), publisher of the Journal of Virology.”Our results suggest that these antibodies might prove therapeutic for MERS patients, and might protect uninfected household members and healthcare workers against MERS,” corresponding author Stanley Perlman, MD, PhD, said in the release. He is a professor in the departments of microbiology and pediatrics at the University of Iowa.Mar 18 J Virol study Mar 30 ASM press release Study: Sofosbuvir for hepatitis C cost-effective only in sickest patientsFor cost-effectiveness, oral sofosbuvir-based treatment for hepatitis C virus (HCV) types 2 and 3 would best be reserved for only those patients with advanced liver disease or for whom other treatments have failed, say the authors of a study published yesterday in the Annals of Internal Medicine.The researchers, from Boston Medical Center (BMC), simulated clinical outcomes, measured as quality-adjusted life years (QALYs) gained, and costs in 2013 US dollars for eight treatment strategies, including sofobuvir-based treatments, the first all-oral treatment approved for US HCV infections. They also calculated the incremental cost-effectiveness ratio (ICER) of treatments by dividing additional costs of each treatment into QALYs gained over the next less expensive treatment.They found that for patients with cirrhosis, the ICER of sofosbuvir treatment was less than $100,000 for each QALY gained whether or not patients have been treated previously with other therapies, a cost commonly cited as the “US willingness-to-pay threshold” per QALY gained, say the authors. By contrast, in noncirrhotic HCV patients who are treatment-naive, the cost was calculated as more than $200,000 per QALY gained.The authors give two reasons for the non-cost-effectiveness of sofosbuvir treatment in treatment-naive noncirrhotic HCV patients. First, pegylated interferon-ribavirin, which is less-expensive, has an efficacy rate of about 80% in these patients but is not an option in treatment-experienced patients. Second, the risk of death from HCV is low in patients without cirrhosis, and not all develop cirrhosis, so sofosbuvir therapy does not translate directly into substantial increases in life expectancy in this group.In addition to limiting the candidates for sofosbuvir treatment, the authors say the cost-effectiveness of the treatment could be improved by lowering the cost of the agent. “At its current cost, access to sofosbuvir will likely be unequal and restricted and will limit the number of people ultimately cured of HCV infection in the United States,” they say.Mar 30 Ann Intern Med study abstract Mar 30 BMC press release Resistant infections tied to endoscopes thought to be fully decontaminatedCurrent industry standards for cleaning and maintenance of endoscopes are insufficient for complete decontamination, say the authors of a report on a cluster of antibiotic-resistant Escherichia coli (CRE) infections published yesterday in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA).The cases of 49 patients with AmpC E coli infection who were patients at a hospital in Washington state from January 2012 to August 2013 were reviewed. Gene sequencing showed 35 (71%) of them to have a strain of bacteria with an identical mutation, including all 10 with carbapenem-resistant (CR) infection.All 35 had complicated biliary or pancreatic disease and had undergone endoscopic retrograde cholangiopancreatography (ERCP) at least once during the study period. Mortality at 30 days was 16% overall and 56% for the CR patients.An evaluation of reprocessed ERCP scopes at the hospitalshowed that 2 of 8 were contaminated by the same bacteria on pulsed-field gel electrophoresis. They had all been cleaned at a level exceeding the manufacturer’s guidelines. Environmental cultures were negative, and no breaks in infection-control procedures were known.A press release from SHEA says the hospital has taken “costly and extraordinary measures,” including quarantining and culturing ERCP scopes after cleaning but that even that has not been entirely successful.”We suspect endoscope-associated transmission of pathogenic bacteria might be both more common than recognized and not adequately prevented by current endoscope reprocessing guidelines,” conclude the authors. They suggest re-evaluation of endoscope design and of reprocessing standards and say endoscopists should inform patients of the risk for endoscope-related bacterial transmission.The report comes in the wake of reports in February of antibiotic-resistant infections linked to the use of reusable duodenoscopes in seven patients at a hospital in Los Angeles.Mar 30 Infect Control Hosp Epidemiol study abstract Mar 30 SHEA press release Related Feb 19 CIDRAP News item
Tweet 44 Views 3 comments Share Housing Minister, Reginald AustrieThe Dominica Government’s goal to eradicate pit latrines is progressing as the first phase of the project nears completion.Dubbed the Housing Renovation & Sanitation program, the government has been assisting citizens to repair their homes and erect modern washroom facilities through the Ministry of Housing.“We want to ensure that the sanitation component is in fact captured,” Housing Minister Reginald Austrie told the media on Thursday, February 13.He said the government had in the past, paid a lot of attention to the home renovation aspect of the program, “because at the time we thought it was necessary to do some renovation”.“Now we’ve gotten to a state where we have to address the sanitary situation and so we have allocated a certain percentage of the funds to the constituencies for home renovation and for sanitation”.“We’re hoping that we should complete, by the end of this phase of the project, we should complete anywhere between sixty and seventy washroom facilities,” Austrie stated.The program commenced in six constituencies, namely, Portsmouth, Castle Bruce, St Joseph, Colihaut Wesley and Thibaud.“We have made request for a release of another 1.5 million and we hope to address the concerns of another six constituencies”.Austrie anticipates that the funds will be released within the next two to three weeks so that immediately after the 2014 Carnival celebrations, the second phase of the program will commence.“We can say that right after the Carnival we should be moving to some other constituencies with the home renovation and importantly the sanitation, the washroom aspect because we’re really, really determined to launch a war on pit latrines and to defeat pit latrines in this country”.Meanwhile, the Minister criticized the Opposition United Workers Party for “making fun of the program”.“While the government is seeking to improve the quality and standard of life for its people, the Opposition does not see it necessary to support every single Dominican having a decent washroom and to stop use the bushes and the rivers and the beaches as their washrooms”.Nevertheless, he noted that the government “will remain focused and will continue to deliver to the people on our social agenda and to improve the quality of life for every single Dominica, if not today, but tomorrow and in the future”.Dominica Vibes News Share Share LocalNews Government’s ‘war’ on pit latrines continues by: – February 14, 2014 Sharing is caring!
(1461) Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Other Bestseller Displayed poorly $26.86$49.99 Shop Now Mail Other (33138) ENDS IN Not relevant 0 $0.00 × Report a problem This item is… Other ENDS IN (116) Bestseller Displayed poorly Bestseller Thank you! This will help us improve your ad experience. We will try not to show you such ads again. DEAL OF THE DAY (1009) Add Comments (Max 320 characters) Report a problem This item is… Inappropriate / Offensive $14.99 Fox Sports Go DEAL OF THE DAY Add Comments (Max 320 characters) (35539) Bestseller Report a problem This item is… ENDS IN DEAL OF THE DAY FOX Sports: Stream live NFL, College Footbal… Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Displayed poorly DEAL OF THE DAY ENDS IN × $59.99 $0.00 ENDS IN (1862) × DEAL OF THE DAY × (124) Not relevant Franklin Sports MLB Electronic Baseball … Inappropriate / Offensive Other Not relevant Report a problem This item is… Add Comments (Max 320 characters) $15.29$17.99 Share DEAL OF THE DAY Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Report a problem This item is… Inappropriate / Offensive ENDS IN Report a problem This item is… Share × Inappropriate / Offensive Bestseller Displayed poorly Dude Perfect Signature Bow Nerf Sports Bi… Inappropriate / Offensive × Other Displayed poorly ENDS IN × Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Other Displayed poorly Other By Dave HartLocalSportsJournal.comTigers 6, Royals 5 – Justin Upton’s eighth inning two-run homer propelled the Tigers over the Kansas City Royals on Sunday afternoon.The win help secured the series victory over the Royals, after defeating them on Friday night in comeback fashion 7-6 and losing 5-2 on Saturday.Detroit opened the scoring with a run in the second inning before the Royals tied the game 1-1 in the third.The Tigers quickly regained their lead in the fourth on a solo home run from J.D. Martinez, then added two runs in the seventh inning to take a 4-1 advantage.Kansas City responded in the bottom of the seventh, scoring four runs to take a 5-4 lead.Upton blasted a two-run homer in the eighth inning to give Detroit a one-run lead.Tigers’ closer Francisco Rodriguez, who picked up his 38th save of the season, allowed a leadoff double in the ninth but stranded him at third base.Detroit was led by Ian Kinsler with three hits and an RBI while Upton doubled, homered and knocked in three runs.Daniel Norris tossed a no-decision for the Tigers, allowing three runs on four hits while striking out seven batters in six innings.Tigers’ relief pitcher Shane Greene picked up the win by pitching 1 1/3 hitless innings.The Tigers are now 74-62 on the season, good for second place in the American League Central Division behind the Cleveland Indians. They are tied with the Baltimore Orioles for the final playoff spot.Detroit will continue its road trip on Monday afternoon against the Chicago White Sox.Record: 74-622nd Place in AL Central Division (5 games behind first-place Cleveland)Tied with Baltimore for the last playoff spotMagic # to clinch a playoff spot: 27Magic # to clinch an AL Central Division title: 33Next Game: 09/05/2016 @ Chicago White Sox 4:10 p.m. @ US Cellular FieldHitting stats: Justin Upton 2B (24) HR (20) 3 RBI (64), J.D. Martinez HR (20) RBI (56), Andrew Romine 2B (3) RBI (13) SB (7), Ian Kinsler RBI (72), Tyler Collins 2B (2).Pitching stats: Shane Greene W (3-3) 1.1 IP 0 H 0 R 0 ER 1 BB 1 K, Francisco Rodriguez SV (38) 1 IP 1 H 0 R 0 ER 0 BB 0 K, Daniel Norris 6 IP 4 H 3 R 3 ER 1 BB 7 K. Ads by Amazon Not relevant NBC Sports $0.00 Ads by Amazon Not relevant Thank you! This will help us improve your ad experience. We will try not to show you such ads again. DEAL OF THE DAY (8187) Shares Inappropriate / Offensive Inappropriate / Offensive Not relevant Report a problem This item is… Get Better Displayed poorly Displayed poorly Not relevant Bestseller Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Other Not relevant Inappropriate / Offensive ENDS IN Add Comments (Max 320 characters) Bestseller × Thank you! This will help us improve your ad experience. We will try not to show you such ads again. Add Comments (Max 320 characters) Add Comments (Max 320 characters) The League Report a problem This item is… Add Comments (Max 320 characters) DEAL OF THE DAY Add Comments (Max 320 characters) Range: Why Generalists Triumph in a Special… Bestseller