HSD3B1(1245C) associated with aggressive disease, shorter survival in men with metastatic prostate cancer: Cleveland Clinic-led study

first_img HSD3B1(1245C) may help physicians identify patients most likely to benefit from additional and more aggressive treatmentIn a new Cleveland Clinic-led study in the US published in JAMA Oncology, researchers show that a testosterone-related genetic variant – HSD3B1(1245C) – is associated with more aggressive disease and shorter survival in men with metastatic prostate cancer.This study – the first clinical trial validation of the relationship between HSD3B1 status and clinical outcomes – suggests that genetic testing for HSD3B1(1245C) may help physicians identify patients most likely to benefit from additional and more aggressive treatment.Dr Nima Sharifi of Cleveland Clinic’s Lerner Research Institute, and colleagues retrospectively analysed data from 475 participants enrolled in a large, multi-centre national clinical trial testing the efficacy of androgen deprivation therapy (ADT) alone or in combination with docetaxel in prostate cancer. They compared clinical outcomes between men who carried the variant versus those who did not.The researchers found that HSD3B1(1245C) inheritance is associated with faster progression to treatment resistance and shorter overall survival in men with low-volume metastatic prostate cancer regardless of the use of docetaxel. Interestingly, the genetic variant led to shortened survival despite the administration of any other therapies following the development of treatment resistance.“These findings lay the groundwork for more personalised and effective treatments for prostate cancer,” said Dr Sharifi, senior author of the study. “If men carry this specific testosterone-related genetic abnormality we may be able to individualise their therapy.”In addition, HSD3B1(1245C) was not found to influence clinical outcomes in men with high-volume prostate cancer. Dr Sharifi notes this is not surprising as previous studies have shown that disease progression and burden is vastly different between high- and low-volume prostate cancer.Taken together, these findings suggest that the presence or absence of this genetic variant can be used to help identify men with low-volume metastatic prostate cancer most at risk for quick progression to treatment resistance and earlier death – a discovery with significant implications for clinical care and genetic counselling.A limitation of the study was a lack of diversity due to the patient population enrolled in the original clinical trial and genetic variant frequencies. Validating this association with a more diverse population will be an important next line of investigation.In 2013, Dr Sharifi made the discovery that the HSD3B1(1245C) variant helps prostate cancer cells evade ADT, the first line of defence against the disease. ADT works by cutting off cells’ supply of testicular androgens, hormones that fuel cancer cells to grow and spread. He showed that in men with the genetic change, cancer cells adapt to produce their own androgens, which leads to treatment-resistant prostate cancer. In 2017, he received the national Top Ten Clinical Achievement Award from the Clinical Research Forum for his discoveries linking HSD3B1(1245C) with poor prostate cancer outcomes.“These findings represent a seven-year research story that started at the lab bench and has now reached the patient bedside,” said Dr Sharifi. “As the team has shown here, incorporating genetic testing in prostate cancer as part of routine care has significant potential to improve treatment success and quality and length of life for men with prostate cancer who carry the HSD3B1(1245C) variant. This work is another step in that direction.”Dr Sharifi holds the Kendrick Family Chair for Prostate Cancer Research at Cleveland Clinic and directs the Cleveland Clinic Genitourinary Malignancies Research Center. He has joint appointments in the Glickman Urological & Kidney Institute and Taussig Cancer Institute.Dr Jason Hearn, Department of Radiation Oncology, University of Michigan, is first author on the study, which was supported in part by the National Cancer Institute, part of the National Institutes of Health, the US Department of Defense and the Prostate Cancer Foundation. Menopause to become the next game-changer in global femtech solutions industry by 2025 Cleveland ClinicDr Nima SharifiHSD3B1(1245C)JAMA Oncologymetastatic prostate cancer Phoenix Business Consulting invests in telehealth platform Healpha HSD3B1(1245C) associated with aggressive disease, shorter survival in men with metastatic prostate cancer: Cleveland Clinic-led study By EH News Bureau on February 24, 2020 MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” Related Posts Read Article WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionals Share The missing informal workers in India’s vaccine story Comments (0) Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19” News Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app Add Commentlast_img read more

Jamaicans Urged to Celebrate Products of Excellence

first_imgJamaicans Urged to Celebrate Products of Excellence JusticeMarch 16, 2010 RelatedJamaicans Urged to Celebrate Products of Excellence RelatedJamaicans Urged to Celebrate Products of Excellence RelatedJamaicans Urged to Celebrate Products of Excellencecenter_img FacebookTwitterWhatsAppEmail Respected international judge Hon. Patrick Robinson has called on Jamaicans to highlight the positives of the country, including its products of excellence.Citing the late Professor Ralston “Rex” Nettleford as among Jamaica’s products of excellence, he also mentioned reggae icon, Bob Marley, Jamaican women, track and field (athletics), and reggae music, as areas in which “we are outstanding, exceptionally good, beyond lofty, beyond limit.”Justice Robinson, who is the President of the International Criminal Tribunal, was addressing patrons at the 22nd annual dinner and dance of the Jamaica College Old Boys Association of Canada (JCOBACA) held recently in Toronto.He lauded Nettleford for the significant role he played in building the confidence of the Jamaican, particularly the disadvantaged Jamaicans, and stated that the Jamaican woman is the backbone of the country’s family and society.He noted that Bob Marley is the most well-known Jamaican worldwide, and Jamaica is best known for its reggae music “principally through the work of Bob Marley.”“The contribution of music to our culture, to the Jamaican heritage and most important to our self-knowledge and identity as a people, is beyond lofty, beyond limits. Music is the most popular element in the Jamaican culture. There is scarcely anything more Jamaican than our music. It’s embedded in the psyche of our people. The songs, their music, their lyrics, their dances, reflect the essence of being Jamaican in a way that nothing else does,” he stated.When Olympic and world champion sprinter Usain Bolt performed the dances, Nuh Linga and Gully Creepa, during the 2008 Beijing Olympics, Justice Robinson said he was not putting on a show, but simply being Jamaican.However, the judge warned that Jamaican music must uplift and Jamaicans must reject music, which debases, degrades and objectifies women, and encourages violence.In the area of track and field, Judge Robinson who has penned a book called: ‘Jamaican Athletics: A Model For 2012 and The World’, noted that since 1948, Jamaican athletes have won 13 gold medals, 27 silver medals and 21 bronze medals at the Olympic Games; and another 14 gold, 33 silver and 13 bronze medals at the World Championships.Urging Jamaicans to highlight the good in the country and stop portraying the negatives, he said that those who strive for excellence but fall short should be encouraged to renew their efforts.Noting that one of the biggest obstacles to the achievement of excellence in Jamaica is the legacy of self-doubt he said: “never underestimate the evil that has been done to our thinking and how it has retarded growth and development in many areas of national life.”President of the JCOBACA, Charles Francis thanked the patrons for their support over the years noting that through their contributions the Association has been able to meet its goals. Over the years, the JCOBACA has provided computers and software, printers, thousands of books, overhead projectors, microscopes and other equipment to the school.In attendance were Jamaica’s Consul General to Toronto, Mr. George Ramocan and Mrs. Lola Ramocan; Chancellor of Ryerson University, Dr. G. Raymond Chang; and former Speaker of the Ontario Legislature, Dr. Alvin Curling.Justice Robinson, who began his legal career at the Office of the Director of Public Prosecutions, is a former student of the University of the West Indies, University of London and Jamaica College. He was honoured with the Order of Jamaica in 2009 for outstanding contribution in the field of International Law and Relations. Advertisementslast_img read more

Fisher House

first_img652 Joel Drive270-798-8330www.fortcampbellwww.fisherhouse.orgwww.facebook.com/KYFisherHouseCFC# 55546The Fort Campbell Fisher House provides lodging to families in a home atmosphere while here to support and care for active duty, retired, veteran and dependent patients receiving qualified treatment at Blanchfield Army Community Hospital or other local medical facilities. It is located directly across the main entrance of Blanchfield and is within walking distance of most on post facilities.Up to eight families can share the home, including the fully stocked kitchen and laundry room, dining room, library with computer workstation, family room with 55-inch TV, video games, movies and toys. Each family is provided a private guest suite furnished with its own common amenities such as TV, DVD player, hairdryer, Wi-Fi, toiletries and more.last_img read more

Taarabt linked with Besiktas and De Guzman reportedly wanted by Napoli

first_imgBesitkas want Adel Taarabt, according to Turkish media reports. The Istanbul-based club are said to have identified Taarabt as a possible replacement for Manuel Fernandes who recently left them to join Lokomotiv Moscow.Taarabt ended last season on loan at AC Milan from QPR and is desperate to move to the San Siro this summer. AdChoices广告Related West London Sport story: Rangers want £6m to sell TaarabtTaarabt’s future is uncertain following his return to Rangers.Reports in the Netherlands suggest Napoli are interested in QPR transfer target Jonathan de Guzman.Napoli’s former Liverpool and Chelsea boss Rafael Benitez is said to have identified Dutch international De Guzman as a possible signing if he misses out on other targets.Rangers are confident of completing a deal to sign the Villarreal midfielder, who has spent the last two seasons on loan at Swansea. Related West London Sport story: QPR ready to agree £7m De Guzman dealQPR have indicated they will pay £7m for De GuzmanMeanwhile, Hamburg chairman Dietmar Beiersdorfer has insisted he wants Rafael van der Vaart to stay at the German club after Harry Redknapp declared an interest in signing the player.Van der Vaart, 31, played under R’s boss Redknapp at Tottenham and would like to return to the Premier League.But Beiersdorfer told Bild: “He’s irreplaceable. It would be very hard for us to do without him.” Related West London Sport story: Redknapp confirms interest in Van der VaartVan der Vaart is one of several possible signings of interest to Redknapp. For more transfer speculation see Wednesday morning’s Paper Talk See also:QPR linked with Boussoufa and former Arsenal midfielder Song Follow West London Sport on TwitterFind us on Facebooklast_img read more

Der Klassiker: Bayern Edge Dortmund To Move Closer To Bundesliga Title

first_imgBayern Munich took a huge step towards retaining their Bundesliga title with a slim victory in Der Klassiker at second-placed Borussia Dortmund.Joshua Kimmich’s sensational chip from 20 yards put Bayern in front two minutes before halftime.Both sides had gone close to breaking the deadlock before Kimmich’s goal and had efforts cleared off the line.The game had been hyped as an encounter between two of Bundesliga’s most in-form strikers with Dortmund’s Erling Braut Haaland cast in the mould of the young challenger to Bayern’s Robert Lewandowski throne.Both strikers who have both scored 41 goals in 35 domestic games this season – putting them level as top goalscorers in Europe drew blanks but came mightily close to adding to their tallies for the season.Haaland had an effort cleared off the line just 35 seconds into the encounter with Jerome Boateng well placed to divert the ball after Manuel Neuer – making his 400th Bundesliga appearance – had been beaten.Lewandowski nearly doubled Bayern’s advantage late on but shot against the post.Shorn of the intimidating “Yellow Wall” at an empty Iduna Signal Park, Dortmund struggled to make much of an impact after the interval with Mahmoud Dahoud’s late effort which was saved by Neuer the closest they got to drawing level.Their second-half performance contrasted with the vibrant showing in the first when they even had the ball in the net but Thorgan Hazard’s effort was ruled out for offside.The win puts Bayern seven points clear of Dortmund with six games remaining and all but puts paid to Dortmund title hopes.In the late kick-offs, 5th-placed Bayer Leverkusen passed up the chance to vault into the top four after they suffered a heavy 4-1 defeat at home by Wolfsburg who are sixth on the log.Eintracht Frankfurt recovered from a 3-1 deficit to draw three all at home to Freiburg and the game between Werder Bremen and Borussia Monchengladbach also ended in a stalemate with both sides settling for a goalless draw. Relatedlast_img read more